Power management mode = Prefer maximum performance
Shadercache = On
DirectX 9 = Pretty smooth gameplay >50 fps, but ALT+Enter and it seems to switch to lower settings compared to Window Mode.
DirectX 10 (with Fixer) = Gameplay is pretty smooth, but less fps than DirectX 9 Window Mode quality is about the same as DirectX 9 Full Screen. However, DirectX 10 only displays a black screen when attempting to enter full screen.
ReShade_Setup_3.1.1.exe in DirectX 9 mode and FSX displays startup screen and then crashes back to the desktop. In DirectX 10, Reshade is completely ignored.